Natural killer/T-cell lymphoma (NKTCL) is an aggressive lymphoma. Glutathione peroxidase 1 (GPX1) is a prevalent isoform with reported roles in various tumors and prognostic implications. However, GPX1’s role in NKTCL remains unclear. This study’s aim is to explore the association of GPX1 expression with NKTCL.
Chemo–immunotherapy is the standard frontline treatment of advanced non–squamous non–small cell lung cancer (nsq–NSCLC). Among oncogenic drivers, KRAS mutation accounts for approximately 25% of lung adenocarcinomas, with p.G12C being the most common variant. This study assessed clinical features and survival outcomes according to KRAS mutation in a real–life population of nsq–NSCLC patients treated with first–line platinum–pemetrexed–pembrolizumab.
This issue contains the following articles:
Cancer prevention and cancer avoidance: Challenges and opportunities
Choriocarcinoma: Diagnosis, treatment and management of a rare germ cell tumour. An update review
Synergistic effects of XPO1 inhibitors combined with CD19 CAR-T cells in TP53-mutated DLBCL
Diagnostic and prognostic role of GPX1 in NK/T cell lymphoma
The clinical usefulness of knowing CHRNA5 polymorphism genotype: paving the way for personalized therapy
ALYREF promotes laryngeal cancer progression through a lactate-mediated lactylation feedback loop that enhances glycolysis
Identification and selection of the best artificial intelligence methods developed for detection and diagnosis of breast cancer
Prevalence and impact of germline mutations in pancreatic ductal adenocarcinoma
Survey among childhood cancer survivors about their preferences on functionalities of a to-be-developed Survivorship Passport Mobile App
BreathBC is a multicenter prospective observational cohort study aimed at comparing metabolic profiles from exhaled breath of patients with breast cancer (BC) and malignancy-free controls. The study accounts for the novelty and complexity of breath analysis, with a particular emphasis on the standardization of each step in the process.
Investigate preferences of childhood cancer survivors (CCS) or of their caregivers (CG) about functionalities of a to be developed mobile app intended to improve compliance with a personalized survivorship care plan (Survivorship Passport) delivered according to the PanCareFollowUp model.
End-of-life care in oncology represents a complex and multidimensional challenge that requires ethical awareness, effective communication, and multidisciplinary collaboration. Drawing from the discussions and data presented during the 2025 AIOM Ethics Days, this paper highlights key aspects influencing the quality and humanity of end-of-life care.
This pilot study aimed at evaluating the feasibility and acceptability of a structured psycho-educational intervention designed to increase disease awareness in children with tumors. The primary objective was to promote psychological adjustment by supporting children’s understanding of their illness and facilitating open parent–child communication about cancer.
The current scientific ecosystem is characterized by a systemic crisis driven by the Publish or Perish culture and an exponential growth in publication volumes that outpaces the number of active researchers. Here, we highlight the limitations of traditional bibliometric indicators, such as the Impact Factor and H-index, which have become targets for manipulation and enable inflationary business models, including the proliferation of special issues.
Comprehensive identification and prioritization of developed artificial intelligence methods for the detection and diagnosis of breast cancer can help to select proper techniques. This study aimed to introduce the best artificial intelligence techniques developed for the detection and diagnosis of breast cancer using microscopic images by fuzzy AHP-TOPSIS techniques.
The daily practice of oncology in Italy is increasingly strained, with bureaucratic rigidity making routine clinical work progressively more difficult. A panel of clinical oncologists, reunited in the DonnaRosa Group, an emerging model of community-based collaboration, where clinicians share real-world challenges and develop actionable strategies, debate the points with the aim of producing some tips to close the gap in clinical practice.