Active surveillance (AS) is standard for early-stage prostate cancer, though intensive monitoring continues due to concerns about reclassification to Grade Group (GG) ⩾ 2. We hypothesized that simple and inexpensive clinical parameters could identify patients with indolent disease for whom less intensive monitoring is safe.
Optimal postoperative follow-up for lung neuroendocrine tumours (L-NET) and surgical resection approaches remain debated. This audit aimed to benchmark long-term outcomes after L-NET surgery at a high-volume centre, identify prognostic factors, and estimate follow-up duration.
Process mining (PM) is a powerful approach for analysing and optimising complex workflows. Radiation therapy (RT) involves multiple steps and resources, making it well suited for PM analysis.
This study aimed to develop radiomics-based multivariate classifiers able to non-invasively decipher the tumor immune microenvironment (TIME) in resected Non-small cell lung cancer (NSCLC) patients.
The increasing complexity of precision medicine has highlighted the limitations of traditional randomized clinical trials (RCTs) when applied to highly stratified populations and biologically heterogeneous diseases. In this context, master protocols represent an evolution towards integrated experimental infrastructures, capable of simultaneously evaluating multiple interventions or molecular subgroups within a single methodological framework.
Authors: Raffaele Giusti and Giampiero Porzio View all authors and affiliations READ THE FULL ISSUE HERE
Circumferential pharyngolaryngectomy (CPL) may result in extensive posterior pharyngeal defects for which standard reconstructive strategies are insufficient. Chimeric flaps from the thoracodorsal system (TDSF) offer independently vascularized components that may address both posterior coverage and luminal restoration. We report what appears to be the first use of a chimeric TDSF for reconstruction following extended CPL.
This issue contains the following articles:
Cancer prevention and cancer avoidance: Challenges and opportunities
Choriocarcinoma: Diagnosis, treatment and management of a rare germ cell tumour. An update review
Synergistic effects of XPO1 inhibitors combined with CD19 CAR-T cells in TP53-mutated DLBCL
Diagnostic and prognostic role of GPX1 in NK/T cell lymphoma
The clinical usefulness of knowing CHRNA5 polymorphism genotype: paving the way for personalized therapy
ALYREF promotes laryngeal cancer progression through a lactate-mediated lactylation feedback loop that enhances glycolysis
Identification and selection of the best artificial intelligence methods developed for detection and diagnosis of breast cancer
Prevalence and impact of germline mutations in pancreatic ductal adenocarcinoma
Survey among childhood cancer survivors about their preferences on functionalities of a to-be-developed Survivorship Passport Mobile App
Few innovative treatments were developed for patients with non-rhabdomyosarcoma soft tissue sarcomas (NRSTS) in the past decades. The paper describes the OCTOPUS project (Optimising Combination Therapy fOr Paediatric, adolescent and yoUng adult patients with non-rhabdomyosarcoma soft tissue Sarcomas), a master protocol and includes an adaptive platform trial comprising different sub-trials, a real-world data registry, translational studies, and overarching study questions assessing local therapy issues and patient reported outcome measures (PROMs).
There is limited data on the safety of switching between CDK4/6i to address toxicity-related permanent discontinuation in patients with HR+/HER2- advanced breast cancer (ABC).