While artificial intelligence (AI) is known to benefit radiotherapy (RT), its applications in carbon ion RT (CIRT) is yet to be surveyed. This scoping review aims to examine the current landscape of AI in CIRT and highlight future directions.
Intratumor heterogeneity (ITH) describes the diversity of cancer cells within a single tumor. This heterogeneity includes differences in the cells’ phenotypes, genotypes, and functions. As a result, cancer cells can vary in their morphology, gene expression and protein profiles, metabolic behavior, and their ability to proliferate and invade surrounding tissues.
Preclinical immunotherapy research relies heavily on animal tumor models, which can be broadly classified into four categories: genetically engineered, carcinogen-induced, spontaneous, and humanized transplantation platforms.
Drawing inspiration from the sitcom Ho Preso un Granchio created by the young patients of the Youth Project at the Istituto Nazionale dei Tumori in Milan, this paper discusses how the depiction of cancer in film and television has changed over the years: specifically, how in 50 years society has gone from being unable to even pronounce the word “cancer” to being able to laugh about it, much like they did, telling their own stories with self-irony and even black humor.
Non–clear cell renal cell carcinoma (nccRCC) represents a heterogeneous group of rare malignancies with limited evidence guiding systemic therapy. The recent introduction of immune checkpoint inhibitors (ICIs) and their combinations with tyrosine kinase inhibitors (TKIs) has shown promising results, but real-world data remain scarce.
Natural killer/T-cell lymphoma (NKTCL) is an aggressive lymphoma. Glutathione peroxidase 1 (GPX1) is a prevalent isoform with reported roles in various tumors and prognostic implications. However, GPX1’s role in NKTCL remains unclear. This study’s aim is to explore the association of GPX1 expression with NKTCL.
Chemo–immunotherapy is the standard frontline treatment of advanced non–squamous non–small cell lung cancer (nsq–NSCLC). Among oncogenic drivers, KRAS mutation accounts for approximately 25% of lung adenocarcinomas, with p.G12C being the most common variant. This study assessed clinical features and survival outcomes according to KRAS mutation in a real–life population of nsq–NSCLC patients treated with first–line platinum–pemetrexed–pembrolizumab.
BreathBC is a multicenter prospective observational cohort study aimed at comparing metabolic profiles from exhaled breath of patients with breast cancer (BC) and malignancy-free controls. The study accounts for the novelty and complexity of breath analysis, with a particular emphasis on the standardization of each step in the process.
Investigate preferences of childhood cancer survivors (CCS) or of their caregivers (CG) about functionalities of a to be developed mobile app intended to improve compliance with a personalized survivorship care plan (Survivorship Passport) delivered according to the PanCareFollowUp model.
End-of-life care in oncology represents a complex and multidimensional challenge that requires ethical awareness, effective communication, and multidisciplinary collaboration. Drawing from the discussions and data presented during the 2025 AIOM Ethics Days, this paper highlights key aspects influencing the quality and humanity of end-of-life care.