Articles - Page 10 of 15 - Tumori Journal

Towards a better registration of neuroendocrine neoplasms: The results of the Italian retrospective population-based study

Research ArticleBy giuliat February 26, 2025

The increasing incidence, rapidly evolving classification, rarity and heterogeneity of neuroendocrine neoplasms (NENs) pose challenges to NEN registration including difficulty in distinguishing neuroendocrine carcinoma (NEC) and neuroendocrine tumours (NETs). Thus, in Italy a higher NEC incidence was reported. Focusing on gastroenteropancreatic (GEP) NEN, we aimed to review GEP NEN, and in particular cases of neuroendocrine carcinoma, not otherwise specified (NOS) and estimate the incidence of NEN, NET and NEC of the GEP.

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ESCO1 as a novel predictive biomarker and potential therapeutic target in renal cell carcinoma

Research ArticleBy giuliat February 16, 2025

Establishment of sister chromatid cohesion N-acetyltransferase 1 (ESCO1) plays an important role in mitosis and is involved in tumor progression of human bladder and prostate cancer. However, its pathological effects on renal cell cancer (RCC) remain unknown. Here, we aimed to assess the impact of ESCO1 down-regulation in RCC cells and explore its role as potential prognosis biomarker for RCC.

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Exploratory analysis of the professional quality of life in an Italian radiotherapy department: The role of empathy and alexithymia

Research ArticleBy giuliat February 9, 2025

Professional quality of life (QoL) is crucial for healthcare workers as it affects performance at work and interaction with patients, but little is known about stressors influencing radiation oncology professionals. The present study aims to explore the professional QoL of radiation oncologists (ROs) and radiation therapists (RTTs) in an Italian radiotherapy department and to report data about the possible impact of personality factors, such as alexithymia and empathy.

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CT-based radiomics: A potential indicator of KRAS mutation in pulmonary adenocarcinoma

Research ArticleBy giuliat February 2, 2025

This study aimed to validate a CT-based radiomics signature for predicting Kirsten rat sarcoma (KRAS) mutation status in lung adenocarcinoma (LADC). A total of 815 LADC patients were included. Radiomics features were extracted from non-contrast-enhanced CT (NECT) and contrast-enhanced CT (CECT) images using Pyradiomics.

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Volume 111 Issue 1, February 2025

Research ArticleBy giuliat February 1, 2025

Read the latest issue. It contains the following articles: Evolving perspectives: Exploring the role of artificial intelligence between clinical practice and health pastoral care, European Cancer Organisation Essential Requirements for Quality Cancer Care for ovarian cancer: Focus on the multidisciplinary team
KRAS inhibitors in drug resistance and potential for combination therapy
Implications and mechanisms of O-GlcNAcylation in cancer therapy resistance
Time trends of cancer incidence in young adults (20-49 years) in Italy. A population – based study, 2008-2017
Fertility and abortion: A population-based comparison between women with cancer and those in childbearing age
Association between clinical factors and the choice of palliative care setting among cancer patients: A post-hoc analysis of a cohort study
Efficacy and safety of PD-1 inhibitor plus chemotherapy in advanced nasopharyngeal carcinoma: A meta-analysis
Bridging bench to bedside: The evolution and impact of translational research in oncology. The experience of the Gruppo Oncologico Italiano di Ricerca Clinica (GOIRC)

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The last journey, coming home before dying for migrant cancer patients: A case series

Case ReportBy giuliat January 30, 2025

Global migration has led to an increasing number of migrant patients receiving cancer diagnoses in foreign countries. These individuals often experience worse outcomes due to advanced disease at diagnosis and limited access to specialized care. When palliative care becomes the primary option, many express a wish to return to their home country for End-of-Life care. However, no guidelines or care pathways currently address this sensitive issue.

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Adjuvant chemotherapy in elderly patients with HER2-negative early breast cancer: A systematic review and meta-analysis

Review ArticleBy giuliat January 30, 2025

Evidence from randomized trials regarding adjuvant chemotherapy and its impact on survival in older patients with resected breast cancer is limited. This study evaluates the current evidence on the use of adjuvant chemotherapy and its effects on overall mortality and breast cancer-specific mortality in older patients.

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Clinical difference between solitary and multiple pulmonary adenocarcinoma nodules

Research ArticleBy giuliat January 24, 2025

We compared and analyzed the imaging features, tumor markers, pathological immunohistochemistry, and lymph node metastasis rates of solitary and multiple lung adenocarcinoma to provide a valuable reference for clinical diagnosis and treatment.

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Efficacy and safety of PD-1 inhibitor plus chemotherapy in advanced nasopharyngeal carcinoma: A meta-analysis

Research ArticleBy giuliat January 10, 2025

The combination of programmed cell death protein 1 (PD-1) inhibitors and chemotherapy has shown promising results in the treatment of various malignancies. This meta-analysis aims to evaluate the effectiveness and safety of combing PD-1 inhibitor with chemotherapy in patients with advanced NPC.

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Implications and mechanisms of O-GlcNAcylation in cancer therapy resistance

Review ArticleBy giuliat December 24, 2024

O-linked-N-acetylglucosaminylation (O-GlcNAcylation), one of the protein post-translational modifications, is the process of adding O-linked-β-D-N-acetylglucosaminylation (O-GlcNAc) to serine and threonine residues of proteins. O-GlcNAcylation regulates various fundamental cell biological processes, including gene transcription, signal transduction, and cellular metabolism.

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