This retrospective single-center observational study aimed to describe our experience of admitting patients based on palliative care needs rather than discontinuation of anticancer treatment.
Re-irradiation is increasingly recognized as a viable and safe treatment option for prostate cancer (PCa) local recurrence. The aim of this study is to present the safety profile, feasibility, and efficacy of a third radiation therapy (RT) course with stereotactic image-guided technique for PCa local relapse through a retrospective analysis of a tertiary centre experience.
While artificial intelligence (AI) is known to benefit radiotherapy (Ewing sarcoma (ES) occurs in the head and neck (HN) region in fewer than 10% of cases, presenting distinct therapeutic challenges.
We retrospectively reviewed all ES cases diagnosed at our institution from 2000 to 2022.
Of 131 patients, 10 (7.6%) had primary HN tumors (median age: 10 years). Tumor locations included the paranasal sinuses (n=6), jaw (n=2), and skull (n=2). Three patients presented with metastatic disease.RT), its applications in carbon ion RT (CIRT) is yet to be surveyed. This scoping review aims to examine the current landscape of AI in CIRT and highlight future directions.
While artificial intelligence (AI) is known to benefit radiotherapy (RT), its applications in carbon ion RT (CIRT) is yet to be surveyed. This scoping review aims to examine the current landscape of AI in CIRT and highlight future directions.
Intratumor heterogeneity (ITH) describes the diversity of cancer cells within a single tumor. This heterogeneity includes differences in the cells’ phenotypes, genotypes, and functions. As a result, cancer cells can vary in their morphology, gene expression and protein profiles, metabolic behavior, and their ability to proliferate and invade surrounding tissues.
Preclinical immunotherapy research relies heavily on animal tumor models, which can be broadly classified into four categories: genetically engineered, carcinogen-induced, spontaneous, and humanized transplantation platforms.
Drawing inspiration from the sitcom Ho Preso un Granchio created by the young patients of the Youth Project at the Istituto Nazionale dei Tumori in Milan, this paper discusses how the depiction of cancer in film and television has changed over the years: specifically, how in 50 years society has gone from being unable to even pronounce the word “cancer” to being able to laugh about it, much like they did, telling their own stories with self-irony and even black humor.
Non–clear cell renal cell carcinoma (nccRCC) represents a heterogeneous group of rare malignancies with limited evidence guiding systemic therapy. The recent introduction of immune checkpoint inhibitors (ICIs) and their combinations with tyrosine kinase inhibitors (TKIs) has shown promising results, but real-world data remain scarce.
Natural killer/T-cell lymphoma (NKTCL) is an aggressive lymphoma. Glutathione peroxidase 1 (GPX1) is a prevalent isoform with reported roles in various tumors and prognostic implications. However, GPX1’s role in NKTCL remains unclear. This study’s aim is to explore the association of GPX1 expression with NKTCL.
Chemo–immunotherapy is the standard frontline treatment of advanced non–squamous non–small cell lung cancer (nsq–NSCLC). Among oncogenic drivers, KRAS mutation accounts for approximately 25% of lung adenocarcinomas, with p.G12C being the most common variant. This study assessed clinical features and survival outcomes according to KRAS mutation in a real–life population of nsq–NSCLC patients treated with first–line platinum–pemetrexed–pembrolizumab.