The evolution of cinematic language in portraying cancer

Editorial

Drawing inspiration from the sitcom Ho Preso un Granchio created by the young patients of the Youth Project at the Istituto Nazionale dei Tumori in Milan, this paper discusses how the depiction of cancer in film and television has changed over the years: specifically, how in 50 years society has gone from being unable to even pronounce the word “cancer” to being able to laugh about it, much like they did, telling their own stories with self-irony and even black humor.

International multicenter experience of prognostic factors and treatment outcomes of metastatic non-clear cell renal cell carcinoma

Research Article

Non–clear cell renal cell carcinoma (nccRCC) represents a heterogeneous group of rare malignancies with limited evidence guiding systemic therapy. The recent introduction of immune checkpoint inhibitors (ICIs) and their combinations with tyrosine kinase inhibitors (TKIs) has shown promising results, but real-world data remain scarce.

Outcomes of first-line chemo-immunotherapy in advanced non-squamous NSCLC according to KRAS status: An Italian real-world study

Research Article

Chemo–immunotherapy is the standard frontline treatment of advanced non–squamous non–small cell lung cancer (nsq–NSCLC). Among oncogenic drivers, KRAS mutation accounts for approximately 25% of lung adenocarcinomas, with p.G12C being the most common variant. This study assessed clinical features and survival outcomes according to KRAS mutation in a real–life population of nsq–NSCLC patients treated with first–line platinum–pemetrexed–pembrolizumab.

Volume 112 Issue 3, June 2026

Research Article

This issue contains the following articles:
Cancer prevention and cancer avoidance: Challenges and opportunities
Choriocarcinoma: Diagnosis, treatment and management of a rare germ cell tumour. An update review
Synergistic effects of XPO1 inhibitors combined with CD19 CAR-T cells in TP53-mutated DLBCL
Diagnostic and prognostic role of GPX1 in NK/T cell lymphoma
The clinical usefulness of knowing CHRNA5 polymorphism genotype: paving the way for personalized therapy
ALYREF promotes laryngeal cancer progression through a lactate-mediated lactylation feedback loop that enhances glycolysis
Identification and selection of the best artificial intelligence methods developed for detection and diagnosis of breast cancer
Prevalence and impact of germline mutations in pancreatic ductal adenocarcinoma
Survey among childhood cancer survivors about their preferences on functionalities of a to-be-developed Survivorship Passport Mobile App

Ethical challenges and multidisciplinary approaches in end-of-life oncology care: Insights from the 2025 AIOM Ethics Days

Research Article

End-of-life care in oncology represents a complex and multidimensional challenge that requires ethical awareness, effective communication, and multidisciplinary collaboration. Drawing from the discussions and data presented during the 2025 AIOM Ethics Days, this paper highlights key aspects influencing the quality and humanity of end-of-life care.

The “empty speech bubbles”: Explaining cancer through play. A pediatric oncology unit pilot experience

Research Article

This pilot study aimed at evaluating the feasibility and acceptability of a structured psycho-educational intervention designed to increase disease awareness in children with tumors. The primary objective was to promote psychological adjustment by supporting children’s understanding of their illness and facilitating open parent–child communication about cancer.

Ethics in the evaluation of the quality of scientific research: An AIOM-TJ roundtable

Editorial

The current scientific ecosystem is characterized by a systemic crisis driven by the Publish or Perish culture and an exponential growth in publication volumes that outpaces the number of active researchers. Here, we highlight the limitations of traditional bibliometric indicators, such as the Impact Factor and H-index, which have become targets for manipulation and enable inflationary business models, including the proliferation of special issues.