Postoperative radiotherapy for stage IV breast cancer following primary tumor removal: Systematic review and meta-analysis

Review Article

De novo metastatic breast cancer (dnMBC) is diagnosed when breast cancer has spread at presentation and accounts for 5–10% of cases. The benefit of postoperative radiotherapy (PORT) after primary tumor surgery in this setting remains uncertain.
We conducted a review and meta-analysis of observational studies published between 2013 and 2024. Two databases (PubMed and Embase) were searched and the review followed PRISMA 2020 guidelines.

A phase II study of nivolumab plus metformin in pre-treated metastatic renal cell carcinoma patients: NivoMet TWINS-GU002 Study

Research Article

This study evaluates the activity of nivolumab plus metformin in pre-treated metastatic renal cell carcinoma (mRCC) patients.
The NivoMet TWINS-GU002 Study was a prospective, multicentre, single-arm, phase II trial conducted in pre-treated mRCC patients eligible for nivolumab and without diabetes mellitus. Patients received nivolumab (240 mg every two weeks) plus metformin (500 mg orally twice a day) until disease progression.

Pediatric palliative care in patients with brain tumors: Timing, activation, and management of acute events

Research Article

The highest percentage of our patients referred to Pediatric Palliative Care (PPC) are those with brain tumors. Of these, we analyzed PPC activation modes and timing, occurrence of acute events during the period of PPC activation, and the time between acute event and death.
During the period 1 January 2010 to 31 October 2023 approximately 1000 Cranial Nervous System (CNS) tumor patients were treated at Fondazione IRCCS Istituto Nazionale dei Tumori in Milan.

Looking back to move forward: 50 years of epidemiology of lymphohaematopoietic malignancies for prevention, and healthcare planning in Sardinia, Italy

Review Article

The Italian region of Sardinia is the second largest and one of the least populated islands in the Mediterranean Sea. While renowned for its stunning coastline, scientists know it better for the unique genetic features among the local population,1 which have been preserved through millennia of isolation and selective pressure exerted by malaria.

Inter-hospital heterogeneity in the authorizations of off-label cancer drugs: A project by Associazione Italiana di Oncologia Medica

Research Article

This project aimed to describe variability of local evaluations of off-label cancer drug requests by submitting a list of identical requests to different Italian centers.
In October 2024, oncology unit directors listed in the AIOM Libro Bianco were invited to participate, evaluating 11 clinical cases with solid tumors through their internal approval process. Supporting evidence was retrospective in two cases, based on phase II trials in seven, and phase III trials in two. Inter-rater agreement was measured using Fleiss’ kappa.

Predictors of duration of hospital stay for cancer patients admitted due to medical causes: A quality-improvement evaluation

Research Article

Hospital admission is frequently required in the cancer trajectory. In a context of bed shortage, pressure on Emergency Departments and increasing healthcare costs, promoting actions that contain hospital stay is a priority. We studied the variables able to predict longer hospital stays.
We retrospectively retrieved data on consecutive admissions in our cancer inpatient unit in a 6-month period and assessed individual and clinical variables potentially related with duration of hospital stay through univariate and multivariate analysis.

Volume 111 Issue 5, October 2025

Research Article

Read the latest issue. It contains the following articles:
The use of bone-modifying agents in early breast cancer: AIOM Guidelines update and perspectives
Delphi Study on the creation of a Committee of patients, caregivers, and representatives of patient associations
The e-BRAVE study: A prospective web-based cohort and biobank of women carriers of BRCA mutations
An indirect approach to identify the healthcare services for thyroid and melanoma cancer patients in Italy: Epicost-2 project
Association of APOC1 levels and nutritional indices with clinicopathological features and prognostic value in patients with DLBCL
Predicting severe toxicity after head-and-neck cancer RT: Validation of the synergist role of a biological marker and dosimetry
Effects of uniportal 3D video-assisted thoracic surgery lobectomy on postoperative pain and immune function in patients with NSCLC
Medication-related jaw osteonecrosis in metastatic RCC treated with VEGFR-TKIs ± IO and bone agents: A real-world analysis