High throughput sequencing reveals alterations in B cell receptor repertoires associated with the progression of hepatic cirrhosis to hepatocellular carcinoma

Research Article

Hepatocellular carcinoma (HCC) is developed as a consequence of chronic liver cirrhosis, and both diseases are difficult to diagnose and differentiate. Accurate noninvasive biomarkers for HCC and liver cirrhosis are urgently needed. Here we used high-throughput sequencing to characterize the B cell receptor (BCR) repertoires from 36 HCC tumor samples and 10 liver cirrhosis (LC) tissue biopsies to understand the immune alterations during hepatic carcinogenesis.

Preoperative chemo-CIRT in Re/BRe pancreatic cancer: Insights from a multicenter prospective phase II clinical study (NCT03822936)

Research Article

There is debate about the optimal management of borderline resectable (bRe) and resectable (Re) pancreatic ductal adenocarcinoma (PDAC). Both preclinical and clinical evidence showed that carbon ion radiotherapy (CIRT) produces superior control on radioresistant histologies compared to conventional photon beam radiotherapy (RT).

Self-perceived attitudes of Italian oncology nurses towards clinical trial involvement: A cohort observational study

Research Article

Literature is lacking when it comes to oncology nursing attitudes in clinical trial involvement. To assess how Italian oncology nurses perceived their attitudes in clinical trials involvement. An on-line cohort observational study was carried out. Data collected included: sex, years of work experience in oncology field and 10 items assessing participants’ self-perceptions of their attitudes in clinical trials.

Fat necrosis after accelerated partial breast irradiation or hypofractionated whole breast irradiation: A case-control study

Research Article

This study aimed to compare the incidence of fat necrosis after accelerated partial breast irradiation (APBI) vs hypofractionated whole breast irradiation (WBI) in patients with early-stage breast cancer. Data from early-stage breast cancer patients who underwent breast-conserving surgery and adjuvant radiotherapy between 2009 and 2022 were retrospectively collected.

Volume 110 Issue 5

Research Article

Read the latest issue. It contains the following articles: PROACT 2.0: A new open-source tool to improve patient-doctor communication in clinical trials; Melanoma and sex hormones: Pathogenesis, progressive disease and response to treatments
Immunogenicity of radiotherapy on bone metastases from prostate adenocarcinoma: What is the future for the combination with radiotherapy/immunotherapy?; Advances in spatial multi-omics in tumors.

Hot topics in genitourinary cancers: A multidisciplinary discussion on state-of-the-art and latest developments among international experts and patient advocacy

Editorial

Genitourinary cancers present significant challenges to oncologists, necessitating innovative approaches for improved patient outcomes. The ‘Controversies in Genitourinary Cancers’ congress, held in January 2024, convened international experts to address the complexities of prostate, bladder, renal and rare genitourinary cancers.

Volume 110 Issue 4

Research Article

Read the latest issue. It contains the following articles: The power of art and the powers of adolescents with cancer: Age-specific projects at Italian pediatric oncology centers; Non-neoplastic cells as prognostic biomarkers in diffuse large B-cell lymphoma: A system review and meta-analysis; The digital revolution in pathology: Towards a smarter approach to research and treatment; Novel insights into RB1 in prostate cancer lineage plasticity and drug resistance; North-south differences in incidence and surveillance of cutaneous malignant melanoma in Italy; Dosimetric and NTCP analyses for selecting parotid gland cancer patients for proton therapy; Effect of neoadjuvant chemoradiation on anorectal function assessed with anorectal manometry: A systematic review and meta-analysis; A new era for bladder cancer: Enfortumab vedotin and pembrolizumab milestone approval; In reply to Topkan et al.