Practices and views about palliative care at the end of life: A survey of oncologists from the Italian region of Liguria

We conducted an online survey to investigate oncologists’ clinical practices and views on palliative care at the end of life in the Italian region of Liguria. The survey included 29 items divided into three sections: participant characteristics (n=6), hospital resources and practices (n=11), participant practices and views (n=12).

Volume 110 Issue 5

Read the latest issue. It contains the following articles: PROACT 2.0: A new open-source tool to improve patient-doctor communication in clinical trials; Melanoma and sex hormones: Pathogenesis, progressive disease and response to treatments
Immunogenicity of radiotherapy on bone metastases from prostate adenocarcinoma: What is the future for the combination with radiotherapy/immunotherapy?; Advances in spatial multi-omics in tumors.

Hot topics in genitourinary cancers: A multidisciplinary discussion on state-of-the-art and latest developments among international experts and patient advocacy

Genitourinary cancers present significant challenges to oncologists, necessitating innovative approaches for improved patient outcomes. The ‘Controversies in Genitourinary Cancers’ congress, held in January 2024, convened international experts to address the complexities of prostate, bladder, renal and rare genitourinary cancers.

Volume 110 Issue 4

Read the latest issue. It contains the following articles: The power of art and the powers of adolescents with cancer: Age-specific projects at Italian pediatric oncology centers; Non-neoplastic cells as prognostic biomarkers in diffuse large B-cell lymphoma: A system review and meta-analysis; The digital revolution in pathology: Towards a smarter approach to research and treatment; Novel insights into RB1 in prostate cancer lineage plasticity and drug resistance; North-south differences in incidence and surveillance of cutaneous malignant melanoma in Italy; Dosimetric and NTCP analyses for selecting parotid gland cancer patients for proton therapy; Effect of neoadjuvant chemoradiation on anorectal function assessed with anorectal manometry: A systematic review and meta-analysis; A new era for bladder cancer: Enfortumab vedotin and pembrolizumab milestone approval; In reply to Topkan et al.

Is tumour sequencing effective for the identification of germline BRCA1/2 pathogenic variant carriers?

Tumour BRCA1/2 sequencing has progressively increased along with the expanding indications for poly(ADP-ribose) polymerase inhibitors. In our study, we investigated the feasibility and outcomes of a workflow for the identification of germline carriers based on tumour sequencing results. Between April 2020 and December 2022, BRCA1/2 tumour testing results from 2020 patients were reviewed. Analysed tumours included: 323 ovarian, 104 breast, 314 pancreas-biliary, 87 prostate, 374 gastrointestinal, 309 lung, and 509 less common histologies.

Advances in spatial multi-omics in tumors

Single-cell techniques have convincingly demonstrated that tumor tissue usually contains multiple genetically defined cell subclones with different gene mutation sets as well as various transcriptional profiles, but the spatial heterogeneity of the microenvironment and the macrobiological characteristics of the tumor ecosystem have not been described.