Volume 110 Issue 6, December 2024

Read the latest issue. It contains the following articles: Hot topics in genitourinary_cancers: A multidisciplinary discussion on state-of-the-art and latest developments among international experts and patient advocacy.
Proton therapy for pediatric malignancies: Indications and challenges focusing on the oncological landscape
Enhanced patient journey associated with improved overall survival in colon cancer patients: A study by the Ligurian Oncology Network
Practices and views about palliative care at the end of life: A survey of oncologists from the Italian region of Liguria
Effect of body mass index on immune checkpoint inhibitor efficacy in patients with advanced cancer
Self-perceived attitudes of Italian oncology nurses towards clinical trial involvement: A cohort observational study.
Fat necrosis after accelerated partial breast irradiation or hypofractionated whole breast irradiation: A case-control study.
High throughput sequencing reveals alterations in B cell receptor repertoires associated with the progression of hepatic cirrhosis to hepatocellular carcinoma
Preoperative chemo-CIRT in Re/BRe pancreatic cancer: Insights from a multicenter prospective phase lI clinical study_(NCT03822936)
Response to lorlatinib rechallenge in a case of ALK-rearranged metastatic NSCLC with a resistance mutation to second generation TKIs
A case series of non-small cell lung cancer patients with EGFR or HER2 exon 20 insertion in Li Fraumeni syndrome
Multiple targets, germline BRCA1 mutation and HRD in a lung cancer patient: Molecular considerations and treatment decision-making

Time trends of cancer incidence in young adults (20-49 years) in Italy. A population – based study, 2008-2017

To evaluate short-term (2008–2017) cancer incidence trends in Italy for individuals aged 20-49 years by sex and cancer type. Observational study from population-based data collected by 20 Italian Cancer Registries, covering 33% of the Italian population. The age-standardized incidence rates (ASRs), overall and stratified by area, sex, cancer site or type, and major age groups (i.e., 20-39, 40-49), were computed.

KRAS inhibitors in drug resistance and potential for combination therapy

Kirsten Rat Sarcoma (KRAS) is a potent target for cancer therapy because it acts as a signaling hub, engaging in various signaling pathways and regulating a number of cellular functions like cell differentiation, proliferation, and survival. Recently, an emergency approval from the US-FDA has been issued for KRASG12C inhibitors (sotorasib and adagrasib) for metastatic lung cancer treatment.

High throughput sequencing reveals alterations in B cell receptor repertoires associated with the progression of hepatic cirrhosis to hepatocellular carcinoma

Hepatocellular carcinoma (HCC) is developed as a consequence of chronic liver cirrhosis, and both diseases are difficult to diagnose and differentiate. Accurate noninvasive biomarkers for HCC and liver cirrhosis are urgently needed. Here we used high-throughput sequencing to characterize the B cell receptor (BCR) repertoires from 36 HCC tumor samples and 10 liver cirrhosis (LC) tissue biopsies to understand the immune alterations during hepatic carcinogenesis.

Preoperative chemo-CIRT in Re/BRe pancreatic cancer: Insights from a multicenter prospective phase II clinical study (NCT03822936)

There is debate about the optimal management of borderline resectable (bRe) and resectable (Re) pancreatic ductal adenocarcinoma (PDAC). Both preclinical and clinical evidence showed that carbon ion radiotherapy (CIRT) produces superior control on radioresistant histologies compared to conventional photon beam radiotherapy (RT).

Self-perceived attitudes of Italian oncology nurses towards clinical trial involvement: A cohort observational study

Literature is lacking when it comes to oncology nursing attitudes in clinical trial involvement. To assess how Italian oncology nurses perceived their attitudes in clinical trials involvement. An on-line cohort observational study was carried out. Data collected included: sex, years of work experience in oncology field and 10 items assessing participants’ self-perceptions of their attitudes in clinical trials.

Fat necrosis after accelerated partial breast irradiation or hypofractionated whole breast irradiation: A case-control study

This study aimed to compare the incidence of fat necrosis after accelerated partial breast irradiation (APBI) vs hypofractionated whole breast irradiation (WBI) in patients with early-stage breast cancer. Data from early-stage breast cancer patients who underwent breast-conserving surgery and adjuvant radiotherapy between 2009 and 2022 were retrospectively collected.